Version 2.1, full system update from 14.02.2023r

Just after starting:

System.UriFormatException: Invalid URI: The URI is empty.
at System.Uri.CreateThis(String uri, Boolean dontEscape, UriKind uriKind, UriCreationOptions& creationOptions)
at System.Uri..ctor(String uriString)
at GLib.FileAdapter.get_Uri()
at Pinta.MainWindow.LoadUserSettings()
at Pinta.MainWindow.OnActivated()
at GLib.Application.Activated_cb(IntPtr inst)

And then after creating new Image:

System.Reflection.TargetInvocationException: Exception has been thrown by the target of an invocation.
---> System.NullReferenceException: Object reference not set to an instance of an object.
at Pinta.Core.BaseTool.SetCursor(Cursor cursor)
at Pinta.Core.BaseTool.<.ctor>b__14_0(Object _, EventArgs _)
at Pinta.Core.WorkspaceManager.OnActiveDocumentChanged(EventArgs e)
at Pinta.Core.WorkspaceManager.SetActiveDocumentInternal(Document document)
at Pinta.Core.WindowActions.<.ctor>b__11_0(Object o, ActivatedArgs e)
at InvokeStub_ActivatedHandler.Invoke(Object, Object, IntPtr*)
at System.Reflection.MethodInvoker.Invoke(Object obj, IntPtr* args, BindingFlags invokeAttr)
--- End of inner exception stack trace ---
at System.Reflection.MethodInvoker.Invoke(Object obj, IntPtr* args, BindingFlags invokeAttr)
at System.Reflection.RuntimeMethodInfo.Invoke(Object obj, BindingFlags invokeAttr, Binder binder, Object[] parameters, CultureInfo culture)
at System.Delegate.DynamicInvokeImpl(Object[] args)

Upstream bug:
https://bugs.launchpad.net/pinta/+bug/2006570